A large Korean cohort study involving nearly 100,000 men demonstrated that current smokers had the highest hazard ratios for gastric cancer compared to never smokers, with risk increasing in a dose-dependent manner according to pack-years
Int J Environ Res Public Health, 2020
While nicotine upregulates the expression of IL8, the expression of IL1, IL6, TNF, MIP-1, MIP-1, and MCP-1 are downregulated
It is important to note that while e-cigarettes and other nicotine-containing tobacco products may not be as harmful as combustible products when directly compared to each other, they are not safe, have unique harm profiles independent of combustible tobacco, and pose particular health risks for youth